Novel poly-(3-hydroxybutyrate)-based systems for controlled release of anti-inflammatory drug has been studied.\nIbuprofen diffusion processes determine the rate of the release at the early stages of the contact of the system with the\nenvironment (the first 6ââ?¬â??8 h). The coefficient of the release diffusion of a drug depends on its nature, the thickness of the poly-\n(3-hydroxybutyrate) films containing the drug, the concentrations of ibuprofen and the molecular weight of the poly-(3-\nhydroxybutyrate). The technique of central composite design (CCD) was used to map the optimal composition range for process\nparameters; this technique is mainly used to map the optimum ER Tablets. PHB base ER tablet of ibuprofen was prepared by\ndirect compression technique and characterized by physicochemical parameters. The prepared tablets were evaluated for\nphysical properties hardness, friability, disintegration time and in-vitro drug release. The drug release pattern, kinetic profiles as\nwell as the low rate of IF release from the tablet was in satisfactory agreement with kinetics of weight loss measured in-vitro for\nthe PHB Tablet. PHB based Ibuprofen oral extended release tablet successfully extended the ibuprofen release in comparison\nwith HPMC.
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